https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53333 1 s and MTT>145%. Delay time (DT) best estimated the infarct core (AUC = 0.74). The optimal core threshold was a DT >1.5 s. The voxel-based analyses indicated CTP was most accurate in the calcarine (Penumbra-AUC = 0.75, Core-AUC = 0.79) and cerebellar regions (Penumbra-AUC = 0.65, Core-AUC = 0.79). For the volume-based analyses, MTT >160% demonstrated best correlation and smallest mean-volume difference between the penumbral estimate and follow-up MRI (R2 = 0.71). MTT >170% resulted in the smallest mean-volume difference between the core estimate and follow-up MRI, but with poor correlation (R2 = 0.11). Conclusion: CTP has promising diagnostic utility in POCI. Accuracy of CTP varies by brain region. Optimal thresholds to define penumbra were DT >1 s and MTT >145%. The optimal threshold for core was a DT >1.5 s. However, CTP core volume estimates should be interpreted with caution.]]> Wed 28 Feb 2024 16:20:57 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44865 Wed 26 Oct 2022 17:23:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47741 Wed 25 Jan 2023 15:21:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35721 Wed 24 May 2023 12:21:56 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18399 Wed 24 Jun 2015 16:01:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31334 Wed 23 Feb 2022 16:02:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19046 Wed 20 May 2020 07:09:22 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44396 Wed 12 Oct 2022 12:58:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13691 Wed 11 Apr 2018 17:01:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13732 Wed 11 Apr 2018 15:43:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19873 Wed 11 Apr 2018 15:32:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22216 Wed 11 Apr 2018 14:00:50 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13300 Wed 11 Apr 2018 12:52:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21638 Wed 11 Apr 2018 12:44:05 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16960 Wed 11 Apr 2018 12:30:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13687 Wed 11 Apr 2018 09:15:37 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28108 Wed 10 Nov 2021 15:04:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39803 1 nanoprobe for noninvasive visualization of biological events. However, the structure–relaxivity relationship and regulatory mechanism of UFNPs remain elusive. Herein, we developed chemically engineered 3.8 nm ZnxFe₃–xO4@ZnxMnyFe_3–x–x–yO₄ (denoted as Zn_xF@Zn₄Mn₄F) nanoparticles with precise dopants control in both crystalline core and disordered shell as a model system to assess the impact of dopants on the relaxometric properties of UFNPs. It is determined that the core–shell dopant architecture allows the optimal tuning of r1 relaxivity for Z_0.40.4F@Zn_0.40.4Mn_0.2F up to 20.22 mM^–1 s^–1, which is 5.2-fold and 6.5-fold larger than that of the original UFNPs and the clinically used Gd-DTPA. Moreover, the high-performing UFNPs nanoprobe, when conjugated with a targeting moiety AMD3100, enables the in vivo MRI detection of small lung metastasis with greatly enhanced sensitivity. Our results pave the way toward the chemical design of ultrasensitive T₁ nanoprobe for advanced molecular imaging.]]> Wed 10 Aug 2022 13:11:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52196 Wed 04 Oct 2023 15:07:38 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45686 Wed 02 Nov 2022 16:20:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34977 Tue 28 May 2019 13:23:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51991 Tue 26 Sep 2023 11:00:58 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46420 Tue 22 Nov 2022 15:53:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40855 Tue 19 Jul 2022 13:14:15 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50318 300 miles would benefit from EVT, achieving rates of functional independence (modified Rankin Scale [mRS] score of 0-2) at 3 months similar to those patients treated at the comprehensive stroke center in the randomized EVT extended window trials and that the selection of patients with computed tomography perfusion (CTP) at the referring site would be associated with ordinal shift toward better outcomes on the mRS. Methods: This is a retrospective analysis of patients transferred from 31 referring hospitals >300 miles (measured by the most direct road distance) to 9 comprehensive stroke centers in Australia and New Zealand for EVT consideration (April 2016 through May 2021). Results: There were 131 patients; the median age was 64 [53-74] years and the median baseline National Institutes of Health Stroke Scale score was 16 [12-22]. At baseline, 79 patients (60.3%) had noncontrast CT+CT angiography, 52 (39.7%) also had CTP. At the comprehensive stroke center, 114 (87%) patients underwent cerebral angiography, and 96 (73.3%) proceeded to EVT. At 3 months, 62 patients (48.4%) had an mRS score of 0 to 2 and 81 (63.3%) mRS score of 0 to 3. CTP selection at the referring site was not associated with better ordinal scores on the mRS at 3 months (mRS median of 2 [1-3] versus 3 [1-6] in the patients selected with noncontrast CT+CT angiography, P=0.1). Nevertheless, patients selected with CTP were less likely to have an mRS score of 5 to 6 (odds ratio 0.03 [0.01-0.19]; P<0.01). Conclusions: In selected patients transferred >300 miles, there was a benefit for EVT, with outcomes similar to those treated in the comprehensive stroke center in the EVT extended window trials. Remote hospital CTP selection was not associated with ordinal mRS improvement, but was associated with fewer very poor 3-month outcomes.]]> Tue 18 Jul 2023 14:30:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38709 Tue 18 Jan 2022 11:49:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53801 Tue 16 Jan 2024 14:52:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46325 Tue 15 Nov 2022 12:07:00 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43097 Tue 13 Sep 2022 12:40:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34120 Tue 12 Feb 2019 13:13:57 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41391 Tue 02 Aug 2022 17:47:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19652 12 months, with the final meeting occurring during the Stroke Treatment Academy Industry Roundtable (STAIR) on March 9 to 10, 2013, in Washington, DC. This process brought together vascular neurologists, neuroradiologists, neuroimaging research scientists, members of the National Institute of Neurological Disorders and Stroke, industry representatives, and members of the US Food and Drug Administration to discuss stroke imaging research priorities, especially in the light of the recent negative results of acute stroke clinical trials that tested the concept of penumbral imaging selection. The goal of this process was to propose a research roadmap for the next 5 years. STIR recommendations include (1) the use of standard terminology, aligned with the National Institute of Neurological Disorders and Stroke Common Data Elements. ; (2) a standardized imaging assessment of revascularization in acute ischemic stroke trials, including a modified Treatment In Cerebral Ischemia (mTICI) score. ; (3) a standardized process to assess whether ischemic core and penumbral imaging methods meet the requirements to be considered as an acceptable selection tool in acute ischemic stroke trials. ; (4) the characteristics of a clinical and imaging data repository to facilitate the development and testing process described in recommendation no. 3. ; (5) the optimal study design for a clinical trial to evaluate whether advanced imaging adds value in selecting acute ischemic stroke patients for revascularization therapy. ; (6) the structure of a stroke neuroimaging network to implement and coordinate the recommendations listed above. All of these recommendations pertain to research, not to clinical care.]]> Thu 28 May 2020 06:30:04 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49655 Thu 25 May 2023 15:26:39 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51747 Thu 21 Mar 2024 13:55:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39028 n = 11) with a history of multiple self-reported concussions compared with age- and education-matched controls (n = 13) who have had no history of brain trauma. Diffusion-weighted images were acquired with a Siemens 3T scanner. All participants completed a clinical interview. There were no significant differences between groups on measures of depression, anxiety, stress, or post-concussion symptoms; however, NRL players scored significantly higher on the alcohol use disorder identification test (AUDIT). Voxelwise analyses of DTI measures were performed using tract-based spatial statistics (TBSS) with age and AUDIT scores included as covariates. TBSS revealed significantly reduced fractional anisotropy (FA), and increased radial diffusivity (RD), axial diffusivity (AD), and trace (TR) in white matter regions of recently retired NRL players compared with controls. FA was significantly reduced in the right superior longitudinal fasciculus and right corticospinal tract while TR, RD, and AD were increased in these regions, as well as the corpus callosum, forceps major, right uncinate fasciculus, and left corticospinal tract. In summary, DTI in a small cohort of recently retired professional NRL players with a history of multiple concussions showed differences in white matter microstructure compared with age- and education-matched controls with no history of brain trauma.]]> Thu 21 Apr 2022 15:32:34 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52640 Thu 19 Oct 2023 15:19:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38864 Thu 14 Mar 2024 09:06:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33218 Thu 13 Sep 2018 13:57:02 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:933 =20% was observed in 89% (Tmax) to 92% (TTP/FMT/MTT) of patients. Application of a +4s (relative to the contralateral hemisphere) PWI threshold reduced the frequency of positive mismatch volumes (TTP 73%/FMT 68%/Tmax 54%/MTT 43%). Mismatch was not significantly different when assessed with ADC maps. Mismatch volume, calculated with all parameters and thresholds, was not significantly correlated with DWI expansion. In contrast, reperfusion was correlated inversely with infarct growth (R=-0.51; P=0.009). Conclusions-: Deconvolution and application of PWI thresholds provide more conservative estimates of tissue at risk and decrease the frequency of mismatch accordingly. The precise definition may not be critical; however, because reperfusion alters tissue fate irrespective of mismatch.]]> Thu 01 Aug 2019 17:24:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8106 Sat 24 Mar 2018 08:40:01 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7676 Sat 24 Mar 2018 08:39:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13713 Sat 24 Mar 2018 08:24:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13275 Sat 24 Mar 2018 08:15:16 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10763 Sat 24 Mar 2018 08:13:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11723 Sat 24 Mar 2018 08:07:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21715 Sat 24 Mar 2018 08:06:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21587 Sat 24 Mar 2018 08:00:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21179 4 seconds for lesion region of interest. The MR-Tmax >6 seconds perfusion lesion was automatically segmented and registered to CTP. Receiver-operating characteristic analysis determined the optimal CT-Tmax threshold to match MR-Tmax >6 seconds. Agreement of these CT parameters with MR perfusion-diffusion mismatch in coregistered slabs was assessed (mismatch ratio >1.2, absolute mismatch >10 mL, infarct core <70 mL). Results: In analysis of 49 patients (mean onset to CT, 213 minutes; mean CT to MR, 31 minutes), constraining relCBF <31% within the automated relTTP perfusion lesion region of interest reduced the median magnitude of volumetric error (vs diffusion-weighted imaging) from 47.5 mL to 15.8 mL (P<0.001). The optimal CT-Tmax threshold to match MR-Tmax >6 seconds was 6.2 seconds (95% confidence interval, 5.6–7.3 seconds; sensitivity, 91%; specificity, 70%; area under the curve, 0.87). Using CT-Tmax >6 seconds “penumbra” and relTTP-constrained relCBF “core,” CT-based and MRI-based mismatch status was concordant in 90% (kappa=0.80). Conclusions: Quantitative CTP mismatch classification using relCBF and Tmax is similar to perfusion-diffusion MRI. The greater accessibility of CTP may facilitate generalizability of mismatch-based selection in clinical practice and trials.]]> Sat 24 Mar 2018 07:58:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17666 Sat 24 Mar 2018 07:57:48 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17780 1.2 and total coregistered mismatch volume was ≥10 mL. The primary outcome was a comparison of infarct growth in alteplase vs placebo patients with coregistered mismatch. Of 99 patients with baseline diffusion-weighted imaging and perfusion-weighted imaging, coregistration of both images was possible in 95 patients. Coregistered mismatch was present in 93% (88/95) compared to 85% (81/95) with standard volumetric mismatch. In the coregistered mismatch patients, of whom 45 received alteplase and 43 received placebo, the primary outcome measure of geometric mean infarct growth was significantly attenuated by a ratio of 0.58 with alteplase compared to placebo (1.02 vs 1.77; 95% CI, 0.33–0.99; P=0.0459). When using coregistration techniques to determine the presence of mismatch at study entry, alteplase significantly attenuated infarct growth. This highlights the necessity for a randomized, placebo-controlled, phase III clinical trial of alteplase using penumbral selection beyond 3 hours.]]> Sat 24 Mar 2018 07:57:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19971 Sat 24 Mar 2018 07:54:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20972 Sat 24 Mar 2018 07:54:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19728 P<0.001) and smaller baseline diffusion lesion volume (Rho −0.70, P<0.001). In 30 patients without reperfusion at day 3 to 5, deterioration in collateral quality between baseline and subacute imaging was strongly associated with absolute (P=0.02) and relative (P<0.001) infarct growth. The deterioration in collateral grade correlated with increased mean Tmax hypoperfusion severity (Rho −0.68, P<0.001). Deterioration in Tmax hypoperfusion severity was also significantly associated with absolute (P=0.003) and relative (P=0.002) infarct growth. Collateral flow is dynamic and failure is associated with infarct growth.]]> Sat 24 Mar 2018 07:53:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21366 4 to >8 s. Hemorrhagic transformation was classified according to the European Cooperative Acute Stroke Studies criteria. Results: Of the 175 patients, 28 had definite atrial fibrillation, 30 probable atrial fibrillation, 111 no atrial fibrillation, and six were excluded due to insufficient imaging data. At baseline, patients with definite atrial fibrillation had more severe hypoperfusion (median time to maximum >8 s, volume 48 vs. 29 ml, P = 0·02) compared with patients with no atrial fibrillation. At outcome, patients with definite atrial fibrillation had greater infarct growth (median volume 47 vs. 8 ml, P = 0·001), larger infarcts (median volume 75 vs. 23 ml, P = 0·001), more frequent parenchymal hematoma grade hemorrhagic transformation (30% vs. 10%, P = 0·03), worse functional outcomes (median modified Rankin scale score 4 vs. 3, P = 0·03), and higher mortality (36% vs. 16%, P = 0·03) compared with patients with no atrial fibrillation. Definite atrial fibrillation was independently associated with increased parenchymal hematoma (odds ratio = 6·05, 95% confidence interval 1·60–22·83) but not poor functional outcome (modified Rankin scale 3–6, odds ratio = 0·99, 95% confidence interval 0·35–2·80) or mortality (odds ratio = 2·54, 95% confidence interval 0·86–7·49) three-months following stroke, after adjusting for other baseline imbalances. Conclusion: Atrial fibrillation is associated with greater volumes of more severe baseline hypoperfusion, leading to higher infarct growth, more frequent severe hemorrhagic transformation and worse stroke outcomes.]]> Sat 24 Mar 2018 07:51:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6688 Sat 24 Mar 2018 07:46:11 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5712 Sat 24 Mar 2018 07:45:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:117 Sat 24 Mar 2018 07:43:16 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27975 Sat 24 Mar 2018 07:38:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29335 Sat 24 Mar 2018 07:34:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30942 Sat 24 Mar 2018 07:33:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25640 Sat 24 Mar 2018 07:28:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26953 Sat 24 Mar 2018 07:27:03 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28199 Sat 24 Mar 2018 07:23:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26920 70% reperfusion at 24 h) were enrolled to investigate the ischemic penumbra and infarct core, respectively. The final infarct was assessed on 24-h diffusion-weighted imaging (DWI), which was retrospectively matched to the baseline perfusion-weighted imaging (PWI) images by volume or voxel-based analysis. The optimal thresholds that determined by each approach were compared. Results: From June 2009 to Jan 2014, of 50 patients enrolled, 19 patients achieved no reperfusion, and 20 patients reperfused at 24 h. In patients with no reperfusion, Tmax > 6 seconds was proved of the best agreement with the final infarct in both volumetric analysis (ratio: 1.05, 95% limits of agreement:-0.23 to 2.33, P < 0.001) and voxel-by-voxel analysis (sensitivity: 72.3%, specificity: 74.3%). In patients with reperfusion, rMTT>225% (ratio:2.4, 95% limits of agreement: -6.5 to 11.4, P < 0.001) was found of the best volumetric agreement with the final infarct, while Tmax > 5.6 seconds (sensitivity: 76.8%, specificity: 70.3%) performed most accurately in voxel-based analysis. Conclusion: Among Chinese acute stroke patients, volume of Tmax >6 seconds may precisely target ischemic penumbra tissue as good as voxel-based analysis performed, albeit no concordant MRP parameter is found to accurately predict infarct core because reperfusion occurred within 24 h after thrombolysis fails to restrain the infarct growth.]]> Sat 24 Mar 2018 07:23:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23481 Sat 24 Mar 2018 07:13:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46578 2-weighted MRIs were acquired in addition to planning CTs. The pCTs were generated from the MRIs using 7 configurations: 4 GANs (L2, single-scale PL, multiscale PL, weighted multiscale PL), 2 U-Net (L2 and single-scale PL), and the PBM. The imaging endpoints were mean absolute error and mean error, in Hounsfield units, between the reference CT (CT_ref) and the pCT. Dose uncertainties were quantified as mean absolute differences between the dose volume histograms (DVHs) calculated from the CT_ref and pCT obtained by each method. Three-dimensional gamma indexes were analyzed. Results: Considering the image uncertainties in the whole pelvis, GAN L2 and U-Net L2 showed the lowest mean absolute error (≤34.4 Hounsfield units). The mean errors were not different than 0 (P ≤ .05). The PBM provided the highest uncertainties. Very few DVH points differed when comparing GAN L2 or U-Net L2 DVHs and CT_ref DVHs (P ≤ .05). Their dose uncertainties were ≤0.6% for the prostate planning target Volume V_95%, ≤0.5% for the rectum V_70Gy, and ≤0.1% for the bladder V_50Gy. The PBM, U-Net PL, and GAN PL presented the highest systematic dose uncertainties. The gamma pass rates were >99% for all DLMs. The mean calculation time to generate 1 pCT was 15 s for the DLMs and 62 min for the PBM. Conclusions: Generating pCT for MRI dose planning with DLMs and PBM provided low-dose uncertainties. In particular, the GAN L2 and U-Net L2 provided the lowest dose uncertainties together with a low computation time]]> Mon 28 Nov 2022 16:01:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49529 Mon 22 May 2023 08:31:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53905 Mon 22 Jan 2024 15:11:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38715 Mon 20 Nov 2023 15:50:10 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38706 Mon 17 Jan 2022 15:59:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53033 Mon 13 Nov 2023 08:48:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55076 Mon 08 Apr 2024 14:17:28 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55077 Mon 08 Apr 2024 14:16:50 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37624 Mon 01 Mar 2021 15:54:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41309 Mon 01 Aug 2022 12:30:36 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40208 Mon 01 Aug 2022 09:10:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35172 Fri 28 Jun 2019 10:23:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46553 Fri 25 Nov 2022 11:33:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47224 Fri 16 Dec 2022 10:37:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20374 Fri 14 Sep 2018 15:50:59 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46105 Fri 11 Nov 2022 11:44:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36851 Fri 10 Jul 2020 11:32:44 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32135 Fri 04 May 2018 15:36:57 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47876 0.12). in vivo results showed statistically significant diurnal variations (P ≤ 0.05, F > 3.88) for 22 resonances. Bonferroni post-hoc testing showed there was statistically significant increases in metabolite ratios between 0700 and 1700 and these include different moieties of N-acetylaspartate, creatine, choline, myo-inositol, lipids, fucose, glutathione, and homocarnosine. Data Conclusion: 2D L-COSY can detect diurnal physiological variability in neuro-metabolite levels. Thus, time of the day should be considered when planning MRS studies to avoid confounding results. Level of Evidence: 1. Technical Efficacy Stage: 1.]]> Fri 03 Feb 2023 15:17:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49799 Fri 02 Jun 2023 17:06:47 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54564 Fri 01 Mar 2024 11:18:59 AEDT ]]>